Imidacloprid is a broad-spectrum insecticide and lousicide used to control fleas in dogs and cats, and lice in dogs. This drug is registered for use in animals only. A puppy from the 5X treatment group displayed rapid, difficult breathing from 4 to 8 hours following the second treatment. For dogs weighing more than 20 lbs., place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at 3 or 4 spots on the top of the backline from the base of the neck to the upper back in an area inaccessible to licking. The most common breeds associated with this mutation include Collies and Collie crosses. Following the first treatment with Advantage Multi for Dogs alone, two dogs experienced adverse reactions (coughing, vomiting, and dyspnea) that required hospitalization. Six dogs vomited within 1 hour of receiving the test article, 2 of these dogs vomited again at 2 hours, and 1 dog vomited again up to 18 hours post-dosing. How it Works: Advantus Oral Flea Treatment Capsules for Dogs contain Imidacloprid, which safely and effectively kills fleas within one hour of administration and is 96% effective against adult fleas within 4 hours.The capsule is easy to give to your dog and may be given as an occasional dose when you see fleas on your pet or daily if necessary. However, shampooing as often as once weekly may reduce the effectiveness of the product against fleas. At 5X, one dog was observed vomiting three hours after the second treatment. To report a suspected adverse reactions, call 1-800-422-9874. Following treatment with Advantage Multi for Dogs alone or in a dosing regimen with melarsomine dihydrochloride, the following adverse reactions were observed: Dogs Treated with Advantage Multi for Dogs Only n=106, Dogs Treated with Advantage Multi for Dogs + Melarsomine n=108. (See ADVERSE REACTIONS and ANIMAL SAFETY - Safety Study in Heartworm-Positive Dogs.). This drug combination is produced by Bayer is labeled to prevent. For dogs weighing 20 lbs. Laboratory Effectiveness Studies: One dog in a laboratory effectiveness study experienced weakness, depression, and unsteadiness between 6 and 9 days after application of Advantage Multi for Dogs. Tubes/pipettes are available in sizes of 0.4 ml (for dogs 3-9 pounds), 1 ml (for dogs 9.1 – 20 pounds), 2.5 ml (for dogs 20.1 to 55 pounds), and 4 ml (for dogs over 55.1 to 88 pounds). 3. Imidacloprid is used on and off label and is applied topically to the skin to treat flea infestations. The safety of Advantage Multi for Dogs has not been established in breeding, pregnant, or lactating dogs. Do not get in eyes or on clothing. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Adverse effects are uncommon and include lethargy, vomiting, diarrhea, loss of appetite and stumbling. Avoid contact with skin. Advantage Multi ® for Dogs (10 % imidacloprid + 2.5 % moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. 15 Dogs fed up to 41 mg/kg of imidacloprid for a year developed increased cholesterol levels and increased concentration of cytochrome P450. As specified in the following table, administer the entire contents of the Advantage Multi for Dogs tube that correctly corresponds with the body weight of the dog. b Although there is no specific antagonist for avermectin toxicity, even severely affected dogs have completely recovered from avermectin toxicity with intensive veterinary supportive care. Dermal Dose Tolerance Study: Advantage Multi for Dogs was administered topically to 8-month-old Beagle dogs at 10X the recommended dose once. The following adverse events in dogs are listed in decreasing order of reporting frequency: depression/lethargy, vomiting, pruritus, diarrhea, anorexia, hyperactivity, ataxia, trembling, hypersalivation, application site reactions (alopecia, pruritus, lesions, and erythema), seizures, and anaphylaxis/anaphylactic reactions (hives, urticaria, facial swelling, edema of the head). In households with multiple pets, keep each treated dog separated from other treated dogs and other pets for 30 minutes after application to prevent licking the application sites. One tube of appropriate size should normally be applied topically every 30 days. While generally safe and effective when prescribed by a veterinarian, imidacloprid + moxidectin may cause side effects in some animals. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using this data. This is temporary and does not affect the safety and effectiveness of the product. Two puppies each in the 1X, 3X, and 5X groups had decreased appetites within 24 hours post-dosing. The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration. or less, place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at one spot between the shoulder blades. LD50 acute, rats, dermal >5000 mg/kg As a general rule, dogs and cats tolerate imidacloprid very well. Weigh your dog to select the appropriate product strength. Bayer, the Bayer Cross and Advantage Multi are registered trademarks of Bayer. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. The microfilariae count in some heartworm-positive dogs increased or remained unchanged following treatment with Advantage Multi for Dogs alone or in a dosing regimen with melarsomine dihydrochloride. __________________. One dog exhibited shaking (nervousness) 1 hour post-dosing. Do not allow the dog to lick any of the application sites for 30 minutes. Parasitic infections are common and include external parasites (fleas, ticks, mites) and internal parasites (intestinal worms, lungworms, heartworms). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Wash hands thoroughly with soap and warm water after handling. It is important to note that the dog product should only be used on dogs while the cat product should only be used on cats. Microfilariae counts decreased with treatment. Gloves worn to pat the dogs contained an average of 254 ppm of imidacloprid 24 hours following application of the product. Start to kill adult fleas within 1 hour. Advantage Multi for Dogs has not been evaluated in heartworm-positive dogs with class 4 heartworm disease. Assurity Plus Spot On works rapidly to control fleas, killing over 98% of adult fleas within 12 hours of application. The active ingredient in Bayer Tree & Shrub is 1.47% imidacloprid - the same ingredient which they market in Advantage flea control for dogs in a 9.1% solution. Moxidectin is a semisynthetic macrocyclic lactone endectocide derived from the actinomycete Streptomycetes cyaneogriseus noncyanogenus. Stiff hair, a damp appearance of the hair, pink skin, or a slight powdery residue may be observed at the application site on some animals. Using the correct dosage about 15 CC's will work... like i said above , it didn't work very well for me on ticks, but it will kill fleas. Dermal LD 50 of technical imidacloprid for rats is more than 5000 mg/kg. Multiply 0.045 times your dog’s weight for dose The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration. (10.0 mg/kg) imidacloprid and 1.1 mg/lb. Increased RBC, hemoglobin, activated partial thromboplastin, and direct bilirubin were observed in the treated group. Do not apply an amount of solution at any one location that could run off the side of the dog. For consumer questions call 1-800-255-6826. Three dogs treated with Advantage Multi for Dogs in a dosing regimen with melarsomine dihydrochloride died of pulmonary embolism from dead and dying heartworms. (imidacloprid + moxidectin) Topical Solution. Without treatment, this dog was neurologically normal at 24 hours and had a normal appetite by 48 hours post-dosing. Advantage Multi® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. Assurity Plus Spot On's unique formula prevents heartworm disease in cats and dogs while controlling fleas, roundworms and hookworms and ear mites in both species and whipworms, Sarcoptes and Demodex mites in dogs. Hypersensitivity reactions were not seen in the 5X treatment group. It is frequently used in combination with other medications to treat a variety of parasites. Select one or more newsletters to continue. Heartgard dosage is a minimum of 6 mcg/kg (2.72 mcg/lb). Call a poison control center or physician for treatment advice. Exposure to the product has been reported to cause headache; dizziness; and redness, burning, tingling, or numbness of the skin. Spotted areas may appear wet or oily for up to 24 hours. The following adverse events are based on post-approval adverse drug experience reporting. Advantage Multi® is supplied for topical application in dogs and cats. Advocate Topical Solution for Dogs and Cats (with Moxidectin) Advantix Topical Solution for Dogs and Cats (with Permethrin) Seresto Collar for Dogs and Cats (with Flumethrin) Generic products are available. Food Residue Puppies 2 to 8 weeks old treated once at up to 20x the therapeutic dose (200 mg/kg) showed no adverse effects. If the dog is already infested with fleas when the first dose of Advantage Multi for Dogs is administered, adult fleas on the dog will be killed. Advantage Multi (imidacloprid + moxidectin) Topical Solution for Dogs. Note that dogs at the lower end of the weight ranges get twice this much, or even more for very small dogs. Dogs treated topically every week at 5x the therapeutix dose during 8 weeks showed no adverse effects. It's hugely important to get make sure that your dog gets exactly the right dose of medicine, at the correct time intervals. Side effects are uncommon but may include irritation at the application site, or, if the medication is accidentally ingested, drooling, shaking, vomiting, and decreased appetite. (2.5 mg/kg) moxidectin once a month by topical administration. Every effort has been made to ensure the accuracy of the Advantage Multi (imidacloprid + moxidectin) Topical Solution for Dogs information published above. Copyright © 2021 Animalytix LLC. The dose of imidacloprid is based on the weight of the dog. Start to kill adult fleas within 1 hour. Recommended dosage-Been using the Bayer tree & shrub, 1.47% imidicloprid product here since early spring. How it Works: Advantus Oral Flea Treatment Capsules for Dogs contain Imidacloprid, which safely and effectively kills fleas within one hour of administration and is 96% effective against adult fleas within 4 hours.The capsule is easy to give to your dog and may be given as an occasional dose when you see fleas on your pet or daily if necessary. Advantage (also sometimes referred to as Advantage I to differentiate from the alternative formulation, “Advantage II”) is a flea treatment for household pets which contains the active ingredient imidacloprid. Field Study: In a controlled, double-masked, field safety study, Advantage Multi for Dogs was administered to 128 dogs of various breeds, 3 months to 15 years of age, weighing 4 to 157 pounds. The signs in this dog may have been related to peak serum levels of moxidectin, which vary between dogs, and occur between 1 and 21 days after application of Advantage Multi for Dogs. Toxic Dose. The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. If contact with eyes occurs, hold eyelids open and flush with copious amounts of water for 15 minutes. Updated: 2020-12-31. Laboratory Safely Study in Heartworm-Positive Dogs: Advantage Multi for Dogs was administered topically at 1 and 5X the recommended dose every 14 days for 3 treatments to dogs with adult heartworm infections and circulating microfilariae. The treatment schedule should be based on individual veterinary diagnoses and on the local epidemiological situation. The IHC Group. Residues from the fur declined to an average of 4.96 ppm by the end of the first week. While holding the tube in an upright position, remove the cap from the tube. It is best to only apply imidacloprid to healthy dogs that are over seven weeks old. This product is not recommended for use in underweight, pregnant, nursing, debilitated, or geriatric animals. Description. Treatment and Control of Intestinal Nematode Infections: For the treatment and control of intestinal hookworm infections caused by Ancylostoma caninum and Uncinaria stenocephala (adults, immature adults and fourth stage larvae) and roundworm infections caused by Toxocara canis (adults and fourth stage larvae), and Toxascaris leonina (adults), and whipworm infections caused by Trichuris vulpis (adults), Advantage Multi for Dogs should be administered once as a single topical dose. Be certain to complete the prescription unless specifically directed otherwise by your veterinarian. If eye irritation develops or persists, contact a physician. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. The dog should be standing for application. What is this drug? Different doses are available, and you choose the correct one based on the weight of your Lab. Ivermectin has a very wide safety range; dosage for dogs with demodex is 300 mcg/kg, and this amount may be given daily over weeks or months. Advantus (imidacloprid) Oral Dog Flea Treatment, Soft Flea Chews for Dogs 23-110 lbs, 30 doses 4.3 out of 5 stars1,395 K9 advantix II Flea and Tick Prevention for Medium Dogs, 11-20 … Advantage Multi is protected by one or more of the following U.S. patents: 6,232,328, and 6,001,858. Vomiting was seen in one puppy from the 1X treatment group (day 57), in two puppies from the 3X treatment group (days 1 and 79), and in one puppy from the 5X treatment group (day 1). Treatment of Circulating Microfilariae: For the treatment of circulating D. immitis microfilariae in heartworm-positive dogs, Advantage Multi for Dogs should be administered at one-month intervals. (redirects here from imidacloprid) Learn about Advantage for dogs, dosage information, side effects, safety information and uses of this substance can be found here. (See WARNINGS.). Imidacloprid and moxidectin may interact with other medications. (See Contraindications, Warnings, Human Warnings, and Adverse Reactions, for more information.). Twist the cap to break the seal and then remove cap from the tube. Advantage Multi for Dogs kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis). should be treated with the appropriate combination of Advantage Multi for Dogs tubes. In cats, moxidectin is dosed at 10 mg/kg imidacloprid with 1 mg/kg moxidectin (Advantage® Multi) applied topically every 30 days. If a dose is missed and a 30-day interval between doses is exceeded, administer Advantage Multi for Dogs immediately and resume the monthly dosing schedule. No fleas and no problems. Even if your pet appears to feel better, the entire treatment program should be completed to prevent resurgence of the infestation. Imidacloprid and moxidectin is not recommended for use in kittens less than 9 weeks of age or less than 2 pounds. Dermal Safety Study in Ivermectin-Sensitive Collies: Advantage Multi for Dogs was administered topically at 3 and 5X the recommended dose every 28 days for 3 treatments to Collies which had been pre-screened for avermectin sensitivity. All dogs were hospitalized for a minimum of 12 hours following each treatment. Uses of Imidacloprid. To report suspected adverse events and/or obtain a copy of the SDS or for technical assistance, call Bayer Animal Heath at 1-800-422-9874. Topical imidacloprid/moxidectin combination treatment administered 3 times at 28-day intervals, or more frequently, did not eliminate mites from most treated dogs. This drug combination is produced by Bayer and is labeled to treat fleas, heartworms, roundworms, hookworms, whipworms (in dogs) and ear mites (in cats). Store at temperatures between 4°C (39°F) and 25°C (77°F), avoiding excess heat or cold. Dog medications dosage requirements are generally calculated by weight and measured in mg of medicine per pound of body weight. Observations at the application sites included damp, stiff or greasy hair, the appearance of a white deposit on the hair, and mild erythema, which resolved without treatment within 2 to 48 hours. Two dogs vomited, one at 6 hours and one at 6 days post-treatment. Oral Safety Study in Ivermectin-Sensitive Collies: Advantage Multi for Dogs was administered orally to 5 pre-screened ivermectin-sensitive Collies. All dogs received Advantage Multi for Dogs on Study Days 0 and 28; 108 dogs also received melarsomine dihydrochloride on Study Days - 14, 14, and 15. Once-a-month topical solution for the prevention of heartworm disease, the treatment of circulating microfilariae, kills adult fleas, is indicated for the treatment of flea infestations, the treatment and control of sarcoptic mange, as well as the treatment and control of intestinal parasite infections in dogs and puppies that are at least 7 weeks of age and that weigh at least 3 lbs. However, reinfestation from the emergence of pre-existing pupae in the environment may continue to occur for six weeks or longer after treatment is initiated. Advantage Multi for Dogs is indicated for the treatment and control of sarcoptic mange caused by Sarcoptes scabiei var. Advantage Multi® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. DOSAGE AND ADMINISTRATION: The recommended minimum dose is 4.5 mg/lb. Monthly imidacloprid application of 7.5 to 10 mg/kg will rapidly kill existing and reinfesting flea infestations on dogs and break the flea life cycle by killing adult fleas before egg production begins. Heartworm Prevention: For prevention of heartworm disease, Advantage Multi for Dogs should be administered at one-month intervals. Safety Study in Puppies: Advantage Multi for Dogs was applied topically at 1, 3 and 5X the recommended dose to 7-week-old Beagle puppies once every 2 weeks for 6 treatments on days 0, 14, 28, 42, 56, and 70. For the first 30 minutes after application: Ensure that dogs cannot lick the product from application sites on themselves or other treated dogs, and separate treated dogs from one another and from other pets to reduce the risk of accidental ingestion. 2. Serious reactions, including neurologic signs and death have been reported when cats have been exposed (orally and topically) to this product. It is also not recommended for use in. Due to its bitter taste, this drug may cause temporary profuse drooling if ingested. Both have the same formula containing 1.47 percent Imidacloprid just like the Bayer Tree and Shrub Insect Control. Do not use this product (containing 2.5% moxidectin) on cats. In dogs, oral moxidectin is dosed at 1.5 mcg per pound (3 mcg/kg) once monthly in dogs. Advantage Multi for Dogs was used safely in dogs concomitantly receiving ACE inhibitors, anticonvulsants, antihistamines, antimicrobials, chondroprotectants, corticosteroids, immunotherapeutics, MAO inhibitors, NSAIDs, ophthalmic medications, sympathomimetics, synthetic estrogens, thyroid hormones, and urinary acidifiers. Imidacloprid and moxidectin should not be used in animals with known hypersensitivity or allergy to the drug. Have person sip a glass of water if able to swallow. Advantage Multi® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. In dogs the LD 50 is 450 mg/kg of body weight (i.e., in any sample of medium-sized dogs weighing 13 kilograms (29 lb), half of them would be killed after consuming 5,850 mg of imidacloprid, or about ​ … Children should not come in contact with application sites for two (2) hours after application. 56. 7.5 mg Advantus Soft Chews contain 7.5 mg imidacloprid per chew for dogs 4 - 22 lbs. Medication should never be administered without first consulting your veterinarian. It is supplied as a topical solution that collects in the oils of the skin and in hair follicles. (2.5 mg/kg) moxidectin, once a month, by topical administration. Consult with your veterinarian to determine if other drugs your pet is receiving might interact with imidacloprid and moxidectin. and 37.5 mg for dogs weighing 23-110 lbs. body weight. Available for Android and iOS devices. The safety of Advantage Multi for Dogs has not been evaluated when administered on the same day as an adulticide. Oral Safety Study in Beagles: Advantage Multi for Dogs was administered once orally at the recommended topical dose to 12 dogs. Ingestion of this product by dogs may cause serious adverse reactions including depression, salivation, dilated pupils, incoordination, panting, and generalized muscle tremors. a Some dogs are more sensitive to avermectins due to a mutation in the MDR1 gene. Flea Treatment: For the treatment of flea infestations, Advantage Multi for Dogs should be administered at one-month intervals. We comply with the HONcode standard for trustworthy health information -, Advantage Multi (imidacloprid + moxidectin) Topical Solution for Dogs Indications, Warnings and cautions for Advantage Multi (imidacloprid + moxidectin) Topical Solution for Dogs, Direction and dosage information for Advantage Multi (imidacloprid + moxidectin) Topical Solution for Dogs. Dogs in the treated group did not gain as much weight as the control group. Information contained on this site pertains only to the United States of America, and is not intended to provide adequate information for product use. A commercial spot-on product containing imidacloprid on dogs ' fur to people the therapeutix dose during 8 weeks no. Additional occupational safety information. ) way to lookup drug information, identify pills, check and! 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