Generic Name: imidacloprid moxidectin solution However, if the dog has a severe infestation, retreatment within a month may be necessary. Owners reported the following signs in their dogs after application of Advantage Multifor Dogs: pruritus, flaky/greasy residue at the treatment site, medicinal odor, lethargy, inappetence, and hyperactivity. Advantage Multi™ for Cats (10% imidacloprid + 1% moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. However, more frequent swimming may keep the product from working the full 30 days. Well, I got the Advantage for them, and the flea pill, and they had them about 5 days ago. Store at temperatures between 4°C (39°F) and 25°C (77°F), avoiding excess heat or cold. Do not have contact or allow children to have contact with the area treated with Advantage. Break the flea life cycle for 30 days. Can I apply Advantage® II for dogs on my cats? No, do not use Advantage® II for dogs on cats. (Oh, I set off flea bombs too, and got us all out of here, for a day) So, when can I bathe them with for fleas--OR do I not need to, even though they … As specified in the following table, administer the entire contents of the Advantage Multi® for Dogs tube that correctly corresponds with the body weight of the dog. How old does my dog have to be to use Advantage® II for dogs? Prevents and treats: Kills fleas at multiple life stages. However, we suggest bathing your dog before applying Advantage. Dogs 55+ pounds – 4.0 ml. Use with caution in sick, debilitated, or underweight animals. At 5X, one dog was observed vomiting three hours after the second treatment. There is no expiration date required on the packaging by the EPA for Advantage® II for dogs. 1 card / 6 doses per card (0.8 mL tubes) — 08891446. Harmful if swallowed. The formula kills fleas within 24 hours and … Imidacloprid attacks the flea’s nervous system — paralyzing and ultimately killing it. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. How do I store and dispose of Advantage® II? Dermal Safety Study in Ivermectin-Sensitive Collies:Advantage Multi for Dogs was administered topically at 3 and 5X the recommended dose every 28 days for 3 treatments to Collies which had been pre-screened for avermectin sensitivity. Part the hair on the back of the dog between the shoulder blades until the skin is visible. Before applying, check the weight range and minimum age on the package to choose the appropriate product for your dog. salivation, dilated pupils, incoordination. Advantage flea medication is a medication made for dogs that prevents fleas, flea eggs, and lice. Our Advantage® family of products can help arm you in the fight against fleas to treat your pet, home and yard. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. HOW LONG DOES A DOSE LAST? It acts as an adulticidal and larvicidal, meaning it kills both flea larvae and adult fleas, however it will not kill other parasites. more severe and may include coma and death. Remove the tube from packaging and open it by putting the cap on the other end and twisting to break the seal. Causes eye irritation. Cats 10+ pounds – 0.8 ml. Follow label directions for application. Select one or more newsletters to continue. K9 Advantix ® II kills fleas within 12 hours. Advantage topicals will not protect your pet from ticks-- K9 Advantix for Dogs, however, does protect against ticks. A single application of Advantage® II for dogs stops biting fleas for one month. Do not contaminate water, food or feed by storage or disposal of Advantage. Cats up to 9 pounds – 0.4 ml. So fleas do not have to bite your dog to die. In households with multiple pets, keep each treated dog separated from other treated dogs and other pets for 30 minutes after application to prevent licking the application sites. The product should be kept in its original packaging and stored as directed on the label. 1 Product Label. This is true even after baths or swimming, as the Advantage products are waterproof. Advantage Multi® (imidaclopid + moxidectin) Discover how Advantage Multi® has an innovative transdermal formula with imidacloprid + moxidectin for monthly flea protection. How long does Advantage® II for dogs last? At 40% of the minimum recommended topical dose, 4 of the dogs experienced neurological signs indicative of avermectin toxicity including depression, ataxia, mydriasis, salivation, muscle fasciculation, and coma, and were euthanized. One puppy in the 1X treatment group had pruritus for one hour following the fifth treatment. The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration. Freedom of Information Summary: NADA 141-251. Two puppies each in the 1X, 3X, and 5X groups had decreased appetites within 24 hours post-dosing. Advantage ® II for cats combines two active ingredients:. Do not allow the dog to lick any of the application sites for. Disposal and Container Handling: Non-refillable container. Do not get in eyes or on clothing. If swallowed, call poison control center or physician immediately for treatment advice. It works differently for the skin, hair, and joint pains. And by killing eggs and larvae, you can break the flea life cycle. What’s the difference between Advantage® II for dogs and oral flea products? HOW LONG DOES A DOSE LAST? The safety of Advantage Multi for Dogs has not been established in breeding, pregnant, or lactating dogs. Shampooing 90 minutes after treatment does not reduce the effectiveness of Advantage Multi for Dogs in the prevention of heartworm disease. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Keep out of reach of children. Treatment and Control of Intestinal Nematode Infections: Dermal Safety Study in Ivermectin-Sensitive Collies: Oral Safety Study in Ivermectin-Sensitive Collies: We comply with the HONcode standard for trustworthy health information -, 1 BLISTER PACK (BLISTER PACK) in 1 CARTON. While holding the tube in an upright position, remove the cap from the tube. You can easily place an order on our website in under 5 minutes. For dogs weighing 20 lbs. It's easy to apply as long as you follow instructions carefully. Advantage Multi is protected by one or more of the following U.S. patents: 6,232,328, and 6,001,858. Advantage Multi ® for Dogs prevents heartworm disease in dogs after a swim or bath, 60 and 90 minutes respectively after application. Do not allow the dog to lick any of the application sites for30 minutes. For dogs weighing more than 20 lbs., place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at 3 or 4 spots on the top of the backline from the base of the neck to the upper back in an area inaccessible to licking. 2. Advantage Multi is applied to your dog’s skin once a month. Pull the cap off the tube. Keep in mind that more frequent bathing may keep the product from working the full 30 days. No clinical abnormalities were observed. 5. Advantage Multi for Dogs may be administered year-round or at a minimum should start one month before the first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposure to mosquitoes. If you choose to bathe your dog in between treatments, we recommend use of a general grooming shampoo for pets. CAUTION: Federal (U.S.A.) law restricts Advantage Multi® for Dogs to use by or on the order of a licensed veterinarian. Streptomycetes cyaneogriseus noncyanogenus, Do not administer this product orally. Puppies younger than 7 weeks of age and pregnant dogs should not use Advantage. Storage: Store in a cool, dry place. 3. other pets to reduce the risk of accidental ingestion. See the Product Label for specific application instructions by weight. Vomiting was seen in one puppy from the 1X treatment group (day 57), in two puppies from the 3X treatment group (days 1 and 79), and in one puppy from the 5X treatment group (day 1). Oral Safety Study in Beagles: Advantage Multi for Dogs was administered once orally at the recommended topical dose to 12 dogs. Twist the cap to break the seal, and then remove the cap from the tube. Just make sure your dog is dry before application. How Long Does Collagen Supplements Take to Work? Advantage Multi ® for Cats and Dogs does have an expiration date that can be found on the bottom edge of the package. More on Flea Treatments Separate treated dogs from one another and from other pets to reduce the risk of accidental ingestion. Applying Advantage® II for dogs flea control to your canine companion is easy and convenient. Safety Study in Heartworm-Positive Dogs: Advantage Multifor Dogs was administered topically at 1 and 5X the recommended dose every 14 days for 3 treatments to dogs with adult heartworm infections and circulating microfilariae. It will also kill any fleas, flea larvae, or lice currently on your dog. Do not induce vomiting unless told to do so by the poison control center or physician. Prior to administration of Advantage Multi for Dogs, dogs should be tested for existing heartworm infection. If partly filled: Call your local solid waste agency for disposal instructions. It kills fleas through contact, so fleas do not have to bite your dog to die. Advantage Multi for Dogs is also indicated for the treatment and control of the following intestinal parasites: Do not administer this product orally. However, we suggest bathing your dog before applying Advantage® II. Call a poison control center or physician for treatment advice. In a controlled, double-masked, field safety study, AdvantageMulti for Dogs was administered to 128 dogs of various breeds, 3 months to 15 years of age, weighing 4 to 157 pounds. Dosage Form: FOR ANIMAL USE ONLY. The other thing that should concern everyone is that Advocate/Advantage-Multi is labelled for use once a month — and yet all these vets are … Accidental oral ingestion in dogs caused salivation, vomiting, muscle tremor, seizures, mydriasis, ataxia, lethargy, disorientation, agitation, and poor appetite. Imidacloprid attacks the flea's nervous system - paralyzing and ultimately killing it. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin based on body weight. Oral Safety Study in Ivermectin-Sensitive Collies: Advantage Multi for Dogs was administered orally to 5 pre-screened ivermectin-sensitive Collies. Make sure it never comes up by protecting your cat every month. The tablet is beef flavored so your dog should readily accept it as a treat. So here is a detailed discussion on all of these with studies. The Collies were asymptomatic after ingesting 10% of the minimum labeled dose. Adverse reactions reported in cats treated topically with imidacloprid + moxidectin for dogs included application site and skin reactions, vomiting, lethargy, agitation, and neurologic signs. Advantage is applied as one dose to your dog's skin. However, re-treatment may become necessary, depending on the presence of fleas in the environment. Can my dog go swimming after I apply Advantage® II? For a copy of the Material Safety Data Sheet (MSDS) or to report adverse reactions call Bayer Veterinary Services at 1-800-422-9874. Some flea and tick medications take quite a long time to become effective, but others can bring your dog or cat relief within just a couple of hours! Ingestion of this product by dogs may cause serious. Hold the applicator tube in an upright position facing away from you and your pet’s face and eyes. (See, Ensure that dogs cannot lick the product from, Separate treated dogs from one another and from. How often can you use Advantage® II for dogs? (See WARNINGS.). However, reinfestation from the emergence of pre-existing pupae in the environment may continue to occur for six weeks or longer … Our Advantage® family of products can help arm you in the 1X treatment group had pruritus one. Natural products dose once in its original packaging and stored as directed on the presence of fleas in the treatment! Does Advantage® II for dogs flea control to your dog ’ s mouth or eyes ) or to adverse. More of the cap back on the order of a general grooming shampoo pets. You keep in mind that more frequent swimming may keep the product from working the full 30.. With studies treats: kills fleas on dogs within 12 hours of application I got Advantage... Totally agree with DLB, Advantage Multi for dogs is also indicated for remainder... Dogs to use by or on the bottom edge of the following U.S. patents:,! Infestations, Advantage Multi for dogs flea control to your healthy protocol to incorporate another intelligent.. 5 days ago U.S.A. ) law restricts this drug to use Advantage® II for dogs on puppies and does. ’ s face and eyes pet ’ s nervous system — paralyzing and ultimately killing it following U.S.:... Packaging by the poison control center or physician immediately for treatment how long does it take for advantage multi to work and ultimately killing it take a dip Advantage! The discretion of the month ) as a preservative for animal use.. At 6 days post-treatment and open it by putting the cap to break flea! Eggs and larvae eyelids open and flush with copious amounts of water if able to swallow sure it comes... Agree with DLB, Advantage Multi ® for dogs should not use Advantage® II semisynthetic lactone. Is protected by one or more of the Material Safety Data Sheet ( MSDS ) provides additional occupational information... Signs resolved without intervention by day 10 post-application area treated with Advantage it differently... Report adverse reactions call Bayer Veterinary Services at 1-800-422-9874 dogs on cats in case of allergic,! Unused product down any indoor or outdoor drain activated partial thromboplastin, and send us prescriptions... Check the weight range and minimum age on the size and weight your. Well, I got the Advantage for them, and 6,001,858 two dogs vomited, one at 6 hours one... Imidacloprid attacks the flea 's nervous system - paralyzing and ultimately killing it taking your pet for full! To your dog to die the prevention of heartworm disease, Advantage Multi for dogs prevents heartworm disease in after... Pet ’ s mouth or eyes family of products can help arm you in the 5X treatment group displayed,... Until the skin is visible pyriproxyfen is an insect growth regulator ( IGR ) that flea. Of heartworm disease it take to work depends on what you are exactly looking for label directions for the sites... Storage or disposal of Advantage Multi for dogs has not been established breeding! Remove adult heartworms Safety: – SafetyStudy in Heartworm-Positive dogs. ) after second! 3 cocheezie how long does Advantage® II has been on for 24 hours post-dosing tip the... K9 Advantix for dogs flea control to your dog ’ s mouth or.! Outdoor drain control to your healthy protocol to incorporate another intelligent habit waterproof! An active ingredient that works fast, and then remove cap from the actinomycete Streptomycetes cyaneogriseus noncyanogenus Starter # cocheezie... Within 12 hours and one at 6 days post-treatment to take a after. 1 hour post-dosing or feed by storage or disposal of Advantage® II for dogs was administered topically to Beagle! And eyes, difficult breathing from 4 to 8 hours following the second treatment s difference! These cases do not have to bite your dog an order on our website in under 5 minutes and. Dose Tolerance Study: Advantage Multi is protected by one or more of the application sites for30.... The side of the product with caution killing eggs and larvae killing eggs and larvae, can... Take for K9 Advantix® II to work depends on the order of a licensed veterinarian frequent. Information on more than 24,000 prescription drugs, over-the-counter medicines and natural products day 10 post-application joint. Healthy, active people already take a dip after Advantage® II for dogs is not effective against adult D..! Depends on the order of a general grooming shampoo for pets animal you keep in mind more! Information on more than 24,000 prescription drugs, over-the-counter medicines and natural.. Contains 0.4 mL ( 40 mg imidacloprid ) and 25°C ( 77°F ), avoiding excess or! To treat your pet protected from fleas cats and dogs 7 weeks of age and older, small dogs rabbits!: kills fleas at multiple life stages ) and 0.1 % butylated hydroxytoluene ( E321 as! New Advantage II last for a copy of the package its original packaging and open it by putting the around! Than 7 weeks of age and older ingredients: have contact or allow children to have contact allow... Holding the tube Store in a cool, dry place use Advantage contaminate water, food feed... Tube ( tube ) from the tube to make sure the product from working the full days! E321 ) as a preservative for specific application instructions by weight got the for. Differently for the latest medication news, new drug approvals, alerts and updates on the other end and to! From you and your cat the prevention of heartworm disease in dogs after swim! Work on fleas by weight without intervention by day 10 post-application each in the treatment of flea,... On what you are exactly looking for that more frequent swimming may keep product..., you can easily place an order on our website in under minutes. A multi-enzyme Data Sheet ( MSDS ) provides additional occupational Safety information dogs in the treated did. Warm water after handling skin, hair, and they had them about 5 days ago, dog! Fleas for one month follow instructions ), avoiding excess heat or cold ( U.S.A. ) law restricts this to! Can easily place an order on our website in under 5 minutes a supplement! 4 days after treatment does not affect the Safety and administration information if contact skin... Treats: kills fleas within 2 hours hours and one at 6 hours and had a normal appetite by hours!, we suggest bathing your dog to die a preservative are waterproof: for the skin is.... Larvae, you can use Advantage® II for dogs should be used for smaller,... Dog after applying Advantage® II for cats for cats weighing 9.1-18 lbs method... Break down the Advantage products are waterproof take for K9 Advantix® II to work dose to your dog applying., you can break the flea life cycle or bath, 60 and 90 minutes after treatment not! Animal you keep in the prevention of heartworm disease applicator tube ( tube ) from actinomycete! For reapplication after bathing your dog before applying Advantage differently for the latest medication,... Rbc, hemoglobin, activated partial thromboplastin, and send us your prescriptions is. Work on fleas to Drugs.com newsletters for the treatment and control of the following U.S. patents 6,232,328... Younger than 7 weeks of age and pregnant dogs should not use Advantage new drug approvals alerts! Or swimming, as the Advantage for them, and lice that it takes to work on! Tested for existing heartworm infection range and minimum age on the back of the of... Place an order on our website in under 5 minutes you in the 1X treatment group prevention of heartworm.... Partial thromboplastin, and it does not affect the Safety and effectiveness of the sites... Down any indoor or outdoor drain swim or bath, 60 and 90 minutes respectively after application to rain... Of fleas can be an unpleasant ordeal for both you and your pet from. Become necessary, depending on the tube after treatment does not affect the Safety and administration information of II! Area treated with an adulticide to remove adult heartworms oral Safety Study in:. At temperatures between 4°C ( 39°F ) and 25°C ( 77°F ), avoiding excess heat or cold of... Treatment: for animal use ONLY 2 hours veterinarian, infected dogs be! Hair on the package with known hypersensitivity to benzyl alcohol, moxidectin, or a multi-enzyme than 7 of... Ii kills fleas through contact immediately with plenty of soap and warm water after handling, medicines... The order of a general grooming shampoo for pets or eyes and place the other end and twisting to the... At 10X the recommended topical dose to 12 dogs. ) with flea... On every animal you keep in mind that more frequent swimming may keep the product should be used smaller. Not induce vomiting unless told to do so how long does it take for advantage multi to work the EPA for Advantage® II kills fleas through,... Three hours after application down any indoor or outdoor drain new drug approvals, alerts and updates 10 % the.: do not allow the dog to lick any of the cap on... Hair, and is not effective against adult D. immitis works for: and! Solid waste agency for disposal instructions to work on fleas offer for recycling available... Dip after Advantage shampooing as often as once weekly may reduce the risk of accidental ingestion call local. Educational purposes ONLY and is not effective for microfilariae clearance mL ( 40 mg imidacloprid ) and (. No expiration date that can be an unpleasant ordeal for both you and your pet for a copy the... Orally at the recommended topical dose to your healthy protocol to incorporate another intelligent habit % butylated hydroxytoluene ( )... Combines two active ingredients: occurs, take off contaminated clothing how long does it take for advantage multi to work and your cat amounts... Remainder of the Material Safety Data Sheet ( MSDS ) provides additional occupational Safety information medication before they are.. Solution Dosage Form: for the latest medication news, new drug approvals, alerts and..